py, 2009, 8 (12):1127-1134. 　　18. Yang RF*, Guo XK, Yang J, Jiang YQ, Pang B, Chen C, Yao YF, Qin JH, Li QT. Genomic research for important pathogenic bacteria in China. Science in China Series C: Life Sciences, 2009,52(1):50-63 　　19. Junwei Yang, Yixuan Zhang, Jing Xu, Yan Geng, Xiaoying Chen,Hongling Yang, Shengnan Wang, Hengan Wang,Xucheng Jiang, Xiaokui Guo, Guoping Zhao* Serum activity of platelet-activating factor acetylhydrolase is a potential clinical marker for leptospirosis pulmonary hemorrhage. PloS ONE. 2009 4(1): e4181. 　　20. Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, Jia PL, Shi TL, Guo XK*. Gene Expression Profiling-Based In Silico Approach to Identify Potential Vaccine Candidates and Drug Targets against B. pertussis and B. parapertussis. OMICS A Journal of Integrative Biology, 2008, 12 (3): 161-169 　　21. Zhang YX, Geng Y, Yang JW, Guo XK, Zhao GP*. Cytotoxic activity and probable apoptotic effect of Sph2, a sphigomyelinase hemolysin from Leptospira interrogans strain Lai. BMB Report, 2008，41(2):119-25 　　22. Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, Zhao GP*, Guo XK*. Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar lai. Infect Immun, 2008, 76(6):2411-9 　　23. He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, Zhang GP, Guo XK*. Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC Genomics, 2007,8:204 　　24. Ying Zou, Guo XK, Mathieu Picardeau, Hai Xu, Guoping Zhao*. A comprehensive survey on isoleucine biosynthesis pathways in seven epidemic Leptospira interrogans reference strains of China. FEMS Microbiology Letters, 2007, 269 (1):90–96 　　25. Guo XK, Zhao WQ, Kondo C, et al. Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2006, 1763(3):296-304 　　26. Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK*. In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans. BMC Genomics, 2006, 16, 7:293 　　27. Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK*. Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. Biochem Biophys Res Commun, 2006, 345(2):858-866 　　28. Qin JH, Sheng YY, Zhang ZM, Shi XZ, He P, Hu BY, Yang Y, Liu SG, Zhao GP, Guo XK*. Genome-wide transcriptional analysis of temperature shift in L. interrogans serovar lai strain 56601.BMC Microbiology, 2006, 6(51):1-10 　　29. Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK. Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation. BMC Infect Dis, 2006,6(1):19 　　30. Li QT, Zhu YZ, Chu JY, Wang YY, Xu YH, Hou QM, Zhang SM, Guo XK*. Protective immUnity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene. Microbiol Immunol, 2006, 50(12):929-36. 　　31. Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY, Zhang SM, Guo XK*. Granulocyte-macrophage Colony-stimulating Factor DNA Prime-protein Boost Strategy to Enhance the Efficacy of a Recombinant Pertus